Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital

Objective: To assess the changes in high sensitivity C Reactive protein (hs-CRP), serum cholesterol, uric acid, creatinine, bilirubin and ALT patients of primary open angle glaucoma.
 Material methods: Comparative cross-sectional study conducted between April 2021 October at departments Ophthalmology Pathology, --removed for blind review----44 POAG 54 healthy controls volunteered to participate study. was diagnosed as per criteria. Venous blood drawn analysis bilirubin, hs-CRP. hs-CRP performed on ELISA plate reader Platos R496 while spectrophotometric cholesterol carried Beckman Coulter AU-700.
 Results: Mean hemoglobin (Hb), Total leukocyte count (TLC), urea, ALT, HbA1c were 12.80 ±1.50g, 8.88±1.92 mm3, 5.95±5.47 µmol/l, 92.19±21.81 305.85±79.92 mmol/l, 34.31±18.26 IU/L, 9.26±3.11 5.18±0.96 mmol/l,6.70±1.28 %respectively whereas IOP 28mmHg, mean CCT 516.6 µm, vertical CDR 0.6.
 High frequency positivity (50 percent) reported our patients. Significantly lower acid levels observed glaucoma versus ie mmol/l vs 344.36±37.24 (P value < 0.05). Serum creatinine significantly different mild severe groups i.e. 88±14.7 113.1±32.4. (p <0.001*)
 Conclusion: low suggest presence para inflammation POAG.
 Key words:
 Primary (POAG), intraocular pressure (IOP), CRP (UA)